Education
Ph.D., Physiology, University of Minnesota, Department of Integrative Biology and Physiology, 2025
Thesis: Unveiling the Pathogenic Role of B cells in Metabolic dysfunction-associated Steatohepatitis"
Advisor: Xavier Revelo, PhD
BS, Biochemistry, Minnesota State University Moorhead, 2017
Awards
- Graduate Student Award Winner: UMN Cardiovascular Retreat 2023 & 2024
- Early Career Investigator Award in Basic Sciences: The Liver Meeting 2021 & 2022
- Beatrice Z. Milne & Theodore Brandenburg Award, UMN, 2023
- Jan Lunden Award: University of Minnesota Medical School, 2022
- Poster of Distinction: The Liver Meeting , 2021
- Scholarship, Keystone Symposia: Fatty Liver Disease and Multi-System Complication, 2021
Funding Awards
- American Heart Association Predoctoral Fellowship, 2022-2024
- Frieda M. Kunze Endowed Fellowship (Declined in favor of AHA Predoctoral fellowship), 2022
- Early Career Investigator Award in Basic Sciences, AASLD: The Liver Meeting, 2022
- Poster of Distinction, AASLD: The Liver Meeting, 2021
- Scholarship, Keystone Symposia: Fatty Liver Disease and Multi-System Complication, 2021
Publications
Barrow F, Fredrickson G, Wang H, and Revelo XS. Functional phenotyping of hepatic lymphocytes in murine MASH by mass cytometry. Star Protocols 2023;4(4):102743.
Barrow F and Revelo XS. The B side of B cells in NAFLD (Invited Editorial). Hepatology 2022 doi: 10.1002/hep.32481.
Barrow F, Khan S, Fredrickson G, Wang H, Dietsche K, Parthiban P, Robert S, Kaiser T, Winer S, Herman A, Adeyi O, Mouzaki M, Khoruts A, Staley C, Hogquist KA, Winer DA, and Revelo XS. Microbiota-Driven Activation of Intrahepatic B Cells Aggravates Nonalcoholic Steatohepatitis through Innate and Adaptive Signaling. Hepatology 2021 74(2):704. Featured in the issue cover.
Barrow F, Khan S, Wang H, and Revelo XS. The Emerging Role of B Cells in the Pathogenesis of NAFLD (Review). Hepatology 2021 74(4):2277.
Wang H, Herman A, Barrow F, Fredrickson G, Parthiban P, and Revelo XS. Single-Cell RNA Sequencing Reveals a Reprogramming of Hepatic Immune Cells and a Protective Role for B cells in MASH-Driven Hepatocellular Carcinoma. Hepatology Communications 2024 [In press].
Liao C, Barrow F, Nakao Y., Mauer A., Fredrickson G, Song M., Sehrawat T., Dasgupta D., Rondell D., Revelo XS, and Malhi H. Modulating sphingosine 1-phosphate receptor signaling skews intrahepatic leukocytes and attenuates murine nonalcoholic steatohepatitis. Frontiers in Immunology 2023 14:1130184.
Fredrickson G, Florczak K, Barrow F, Dietsche K, Parthiban P, Almutlaq R, Abujamra M, Demirchian M, Kieu T, Wang H, Adeyi O, Staley C, Nguyen H, Jahansouz C, Ikramuddin S, and Revelo XS. TREM2 macrophages mediate the beneficial effects of bariatric surgery against NASH. Hepatology 2024 doi: 10.1097/HEP.0000000000001098.
Parthasarathy G, Venkatesan N, Sidhu GS, Song MJ, Liao CY, Barrow F, Mauer A, Sehrawat T, Nakao Y, Daniel PV, Dasgupta D, Pavelko K, Revelo XS, and Harmeet Malhi. Deletion of Sphingosine 1-Phosphate Receptor 1 in Myeloid Cells Reduces Hepatic Inflammatory Macrophages and Attenuates MASH. Hepatology Communications 2024 [In press].
Patterson MT, Xu Y, Hillman H, Osinski V, Schrank PR, Kennedy AE, Barrow F, Zhu A, Tollison S, Shekhar S, Stromnes IM, Tassi I, Wu D, Revelo XS, Binstadt BA, Williams JW. Trem2 Agonist Reprograms Foamy Macrophages to Promote Atherosclerotic Plaque Stability. ATVB 2024; 44(7):1646.
Revelo XS, Parthiban P, Barrow F, Fredrickson G, Wang H, Yücel D, Chen C, and van Berlo J H. Cardiac macrophages prevent fibrosis and stimulate angiogenesis in compensated hypertrophy. Circulation Research 2021 129:1086.
Lopresti MW, Cui W, Abernathy B, Fredrickson G, Barrow F, Desai AS, Revelo XS, and Mashek DG. Hepatic Lysosomal Acid Lipase Overexpression Worsens Hepatic Inflammation in Mice Fed a Western Diet. Journal of Lipid Research 2021 5:100133.
Fredrickson G, Barrow F, Dietsche K, Parthiban P, Khan S, Robert S, Demirchian M, Wang H, and Revelo XS. Exercise of high intensity ameliorates hepatic inflammation and the progression of NASH. Molecular Metabolism 2021 53:101270.
Chakraborty M, Chu K, Shrestha A, Revelo XS, Zhang X, Gold MJ, Khan S, Lee M, Huang C, Akbari M, Barrow F, Chan YT, Kotoulas NK, Jovel J, Pastrello C, Kotlyar C, Goh C, Michelakis E, Clemente-Casares X, Ohashi PS, Engleman EG, Winer S, Jurisica I, Tsai S, and Winer DA. Mechanical Stiffness Controls Dendritic Cell Metabolism and Function. Cell Reports 2021 34(2):108609.
Pre-prints
Barrow F, Wang H, Fredrickson G, Florczak K, Ciske E, Khanal S, Nguyen H, Parthiban P, Kostellari E, and Revelo XS. Pyruvate Oxidation Sustains B Cell Antigen-Specific Activation to Exacerbate MASH. Biorxiv 2023. doi:10.1101/2023.11.13.566832.
Wang H, Barrow F, Fredrickson G, Florczak K, Nguyen H, Parthiban P, Herman A, Adeyi O, Staley C, Ikramuddin S, Ruan H, Jameson S, and Revelo XS. Dysfunctional T Follicular Helper Cells Cause Intestinal and Hepatic Inflammation in NASH. Biorxiv 2023. doi: https://doi.org/10.1101/2023.06.07.544061.
Parthiban P, Barrow F, Nguyen H, Neto F, Florczak K, Wang H, Yücel D, Liu H, Fredrickson G, Herman A, Ciske E, Draxler M, Rothenberg M, van Berlo JH, and Revelo XS. Macrophage-derived CCL24 promotes fibrosis and worsens cardiac dysfunction during heart failure. Biorxiv 2024. doi.org/10.1101/2024.07.12.603277.