Education
Ph.D., Physiology, University of Minnesota, Department of Integrative Biology and Physiology, 2025, Thesis: An essential role for microglial Complement 3a Receptor (C3aR) on high-fat diet induced hypothalamic neuroinflammation: Alessandro Bartolomucci, PhD
BS, Neuroscience, University of Minnesota, 2018
Awards
- People’s Choice Award Winner: UMN Cardiovascular Retreat , 2023
- Top abstract winner, UMN Diabetes Day, 2023
- Minnesota Obesity Prevention Training Program (MnOPT) NIDDK T32DK083250-12. 2021-Present
Publications
Pallais JP, Razzoli M, Rodriguez P, McGonigle S, Hillman H, Schrank P.R., Parthiban P, Chang X, Wang H, Perez de Nanclares C, Köhl J, Revelo X.S., Ruan HB, Araque A, Williams J.W., Bartolomucci A. An essential role for microglial Complement 3a Receptor 1 on high-fat diet induced hypothalamic gliosis. Submitted to Nature Metabolism.
Rodriguez P, Pallais JP, He R, Laskowski LJ, Razzoli M, Finan B, McCorvy JD, Sham YY, DiMarchi R, Bartolomucci A. A novel class of rationally-designed C3aR1 agonists and antagonists derived from TLQP-21 peptide. Submitted to Journal of Medicinal Chemistry.
Parthiban P, Barrow F, Nguyen H, Draxler M, Wang H, Chalise U, Araujo N, Souza-Neta F, Pallais JP, Yucel D, Liu H, Ciske E, Fehrenback P, Lee S.H., Herman A, Rothenberg M.E., Dudley S, van Berlo J.H., Revelo X.S. Macrophage-derived CCL24 promotes cardiac fibrosis through fibroblast-specific CCR3 signaling. Circulation Research. 2025.
Lyons C, Pallais JP, McGonigle S, Mansk R, Collinge C, Yousefzadeh M, Baker D, Schrank P, Williams J.W, Niedernhofer L.J, van Deursen J, Razzoli M, Bartolomucci A. Chronic social stress induces p16-mediated senescent cell accumulation in mice. Nature Aging, 5(1), 48–64. 2024.
Rodriguez P, Laskowski L. J, Pallais JP, Bock H. A, Cavalco N. G, Anderson E. I, Calkins M. M, Razzoli M, Sham Y, McCorvy JD, Bartolomucci A. Functional profiling of the G protein-coupled receptor C3aR1 reveals ligand-mediated biased agonism. Journal of Biological Chemistry, 105549. 2023.
Sahu BS, Nguyen ME, Rodriguez P, Pallais JP, Ghosh V, Razzoli M, Sham YY, Salton SR, Bartolomucci A. The molecular identity of the TLQP-21 peptide receptor. Cell Mol Life Sci, 2021.
Stanojlovic M, Pallais JP, Kotz CM. Inhibition of Orexin/Hypocretin Neurons Ameliorates Elevated Physical Activity and Energy Expenditure in the A53T Mouse Model of Parkinson’s Disease. Int J Mol Sci. 2021.
Rodriguez R, Mansk R, Cero C, Gaviola G, Palanza P, Beetch M, Alejandro E, Sham Y, Frontini A, Salton S, Bartolomucci A. Targeted and selective knockout of the TLQP-21 neuropeptide unmasks its unique role in energy homeostasis. Molecular Metabolism, 2023.
Sahu BS, Nguyen ME, Rodriguez P, Pallais JP, Ghosh V, Razzoli M, Sham YY, Salton SR, Bartolomucci A. The molecular identity of the TLQP-21 peptide receptor. Cell Mol Life Sci, 2021.
Stanojlovic M, Pallais JP, Kotz CM. Inhibition of Orexin/Hypocretin Neurons Ameliorates Elevated Physical Activity and Energy Expenditure in the A53T Mouse Model of Parkinson’s Disease. Int J Mol Sci. 2021.