Education
Postdoctoral Fellow, University of North Carolina, Chapel Hill; University of Parma, Italy
PhD, Animal Behavior, University of Florence, Italy
BS, Biology, University of Parma, Italy
Research summary
I coordinate the invivo activity of the Bartolomucci lab that is primarily focused on the study of behavioral and physiological responses to stress and aging as well as to the mechanisms of metabolic function and dysfunction involving the neuropeptide TLQP-21, using both pharmacological and genetic approaches in murine models of diabetes and obesity. I also serve as Behavior and Metabolism Specialist of the IBP Physiology core, ensuring the availability of several technologies for the characterization of users’ mouse models.
Publications
Razzoli M*, et al. Contextual modifiers of healthspan, lifespan, and epigenome in mice under chronic social stress. Proc Natl Acad Sci U S A. 2023 Apr 18;120(16):e2211755120. *corresponding author.
Lyons CE, Zhou X, Razzoli M, et al. Lifelong chronic psychosocial stress induces a proteomic signature of Alzheimer's disease in wildtype mice. Eur J Neurosci. 2022 May;55(9-10):2971-2985.
Grant MKO, Razzoli M, et al. Juvenile exposure to doxorubicin alters the cardiovascular response to adult-onset psychosocial stress in mice. Stress. 2022 Jan;25(1):291-304.
Sahu BS, Nguyen ME, Rodriguez P, Pallais JP, Ghosh V, Razzoli M, et al. The molecular identity of the TLQP-21 peptide receptor. Cell Mol Life Sci. 2021 Dec;78(23):7133-7144.
Sveidahl Johansen O, Ma T, Hansen JB, Markussen LK, Schreiber R, Reverte-Salisa L, Dong H, Christensen DP, Sun W, Gnad T, Karavaeva I, Nielsen TS, Kooijman S, Cero C, Dmytriyeva O, Shen Y, Razzoli M, et al. Lipolysis drives expression of the constitutively active receptor GPR3 to induce adipose thermogenesis. Cell. 2021 May 22:S0092-8674(21)00572-9.
Razzoli M, et al. Social stress is lethal in the mdx model of Duchenne muscular dystrophy. EBioMedicine. 2020 May;55:102700.
Sahu BS, Rodriguez P, Nguyen ME, Han R, Cero C, Razzoli M, et al. Peptide/Receptor Co-evolution Explains the Lipolytic Function of the Neuropeptide TLQP-21. Cell Rep. 2019 Sep 3;28(10):2567-2580.e6.
Razzoli M, et al. Social Stress Shortens Lifespan in Mice. Aging Cell. 2018 May 28:e12778.
Razzoli M, et al. β-Adrenergic receptors control brown adipose UCP-1 tone and cold response without affecting its circadian rhythmicity. FASEB J. 2018 May 1:fj201800452R.
Razzoli M, et al. Stress, overeating, and obesity: Insights from human studies and preclinical models. Neurosci Biobehav Rev. 2017 May;76(Pt A):154-162.
Cero C, Razzoli M, et al. The neuropeptide TLQP-21 opposes obesity via C3aR1-mediated enhancement of adrenergic-induced lipolysis. Mol Metabol. 2016 Oct 31;6(1):148-158.
Razzoli M, Bartolomucci A. The Dichotomous Effect of Chronic Stress on Obesity. Trends Endocrinol Metab. 2016 May 5. pii: S1043-2760(16)30023-6.
Razzoli M, et al. 2016. Stress-induced activation of brown adipose tissue prevents obesity in conditions of low adaptive thermogenesis. Mol Metabol 5 (2016) 19e33.
Razzoli M, Cero C, Bartolomucci A, 2017. How does stress affect energy balance? Recent advances in physiology and neurobehavioral genetics. In Tucci V (Ed). Phenotyping Behaviour and Cognition. Towards a cutting-edge neurobehavioural genetics. Wiley Book series.
Razzoli M, et al. Chronic stress aggravates glucose intolerance in leptin receptor-deficient (db/db) mice. Genes Nutr. 2015 May;10(3):458.
Razzoli M, Sanghez V, Bartolomucci A. Chronic subordination stress induces hyperphagia and disrupts eating behavior in mice modeling binge-eating-like disorder. Front Nutr. 2015;1(30).
Razzoli M, Bartolomucci A, and Carola V. Gene-by-Environment Mouse Models for Mood Disorders. IN: The Oxford Handbook of Molecular Psychology, Turhan Canli Ed. Oxford University Press. 2015. pp210-222.
Razzoli M, et al.. Chronic subordination stress phase advances adrenal and anterior pituitary clock gene rhythms. Am J Physiol Regul Integr Comp Physiol. 2014 Jul 15;307(2):R198-205.
Sanghez V, Razzoli M, et al. Psychosocial stress induces hyperphagia and exacerbates diet-induced insulin resistance and the manifestations of the Metabolic Syndrome. Psychoneuroendocrinology. 2013 Dec;38(12):2933-42.
Razzoli M, et al. Implication of the VGF-derived peptide TLQP-21 in mouse acute and chronic stress responses. Behav Brain Res. 2012 Apr 15;229(2):333-9.